We offer Food Sensitivity Testing that measures sensitivities to up to 176 different foods, coloring and additives using the Food Inflammation Test, also known as the FIT Test. The test was created by Brent Dorval, Ph. D, who was involved in the creation of the first HIV/AIDS rapid diagnostic assay. In addition to the FIT Test, we offer a Zonulin Test. The FIT test comes in three panels; the FIT 22, 132 and 176.

The FIT Test is the most sensitive food test available using patented technology. The multiple pathway approach allows us to look at not only food sensitivities but also inflammation and gut permeability all from one test. We also provide best in class compliance tools including a personalized meal plan and a client app.

We use the KBMO Diagnostics FDA Registered and ISO 13485 compliant manufacturing facility as well as a CLIA High Complexity Laboratory based near Boston, Massachusetts.

Food Inflammation Testing

There are three main options for the FIT. We recommend reviewing the link below “Foods We Test”  to review how the tests are different. There is no prep for this test. It is a finger prick and takes about 5 minutes. You can come into the office for this test or request a test to be sent directly to your home. Results are typically available in 14 business days. You do NOT have to be client of the clinic to order this test. Additional information and sample reports below.

*We offer a FIT44 ($150) test that is only for returning clients who have done the FIT 132 and would like to test the additional foods, colorings, and additives that were added to the FIT 176. In order to purchase this test, you have to provide the accession number from a previous FIT 132.*

Introduction to Food Inflammation

Food sensitivities and related diseases affect at least 100 million people worldwide. In the USA alone about 50 million people suffer from food sensitivities at a cost of 18 billion dollars per year. In general, the prevalence of food sensitivities has increased to more than 50% in adults and more than 70% in children in the past few years. Food-related reactions cause a wide variety of illnesses ranging from skin rashes and headaches to chronic intestinal diseases. Although the symptoms of food sensitivities may differ, antigens from food, food additives or environmental sources cause the production of antibodies (IgM, IgA, IgG, IgE and IgD) or interact with the mucosa or epidermis and stimulate T-cells. Food sensitivities are classified into four types (I, II, III, IV) based on Gell/Coombs system. The FIT Test measures both Type II and III delayed type reactions mediated by IgG antibodies and Complement bound to immune complexes. IgG antibodies in the blood binds to soluble antigens or antigens which have deposited in tissues and form immune complexes. Immune complexes then activate Complement which becomes bound to the immune complex lattice. Activation of Complement causes tissue inflammation and the symptoms associated with food sensitivities. The FIT Test measures both IgG antibodies and Complement fragments. Other assays measure only IgG resulting in reduced sensitivity.

Food Cross-Reactivity

Foods are composed of many different types of proteins, sugars or chemicals that can be quite similar even among very different food groups. Antibodies which are produced are highly specific in that they react with specific parts of a protein (peptide) or even a chemical. However, dissimilar foods are quite often composed of very similar peptides which results in an antibody that was produced against specific food but also reacts with a different food because of the similarity in a certain peptide. A good example is the cross reactivity of wheat and coffee proteins which are similar. In addition, antibodies against small chemicals such as the additive Benzoic Acid may cross react with food colorings such as Red 3 or Red 40 because they all share a similar phenyl ring. A list of the foods and additives tested in the FIT Test and possible cross-reactivity can be found on our website. The various foods are arranged in tables which correspond to food groups found in the FIT Test.

Click on the symptom below to find out how you can benefit from the FIT.

KBMO has recently announced the Gut Barrier Panel. This test will be included with the FIT132 and FIT176 tests. Providers who strive to differentiate the levels of gut dysfunction, from simple sensitivity to inflammation, and more extreme levels of leaky gut will find the addition of the GB Panel very useful.

KBMO has created a unique Gut Barrier Panel which in recognition that leaky gut occurs across a spectrum they have included the following gatekeeper markers: Candida, Zonulin and Occludin. For each marker, we measure IgG 1-4 /C3d in addition to IgA 1 and 2.

Gut Barrier Panel

Candida

We measure and use any candida overgrowth in the stomach/dysbiosis as a precursor to leaky gut occurrence.

Zonulin

Zonulin is a marker of intestinal permeability, otherwise known as leaky gut. If a patient has elevated Zonulin levels, the normal regulation of the tight junctions is compromised. More information is below.

Occludin

Occludin is a marker of tight junction stabilization and optimal barrier function. Elevated occludin indicates that the tight junctions are breaking down.

Lipopolysaccharides (LPS)

LPS is a major structural component of the outer membrane of gram-negative bacteria. Elevated levels of antibody against LPS may be indicative of Leaky Gut Syndrome and other gastrointestinal inflammatory diseases.

The GB Panel removes the guesswork; providers no longer have to guess they can test for Food Sensitivities, Inflammation and Leaky Gut and then treat their patients accordingly.

Zonulin Testing

Zonulin is a protein that is synthesized in intestinal cells and liver cells. It is a key biomarker for intestinal permeability and is the only regulator of intestinal permeability that is reversible. Zonulin is one of three ways the FIT test can diagnose a leaky gut, along with finding a sensitivity to Candida and multiple Food Sensitivities. It is estimated that anywhere between 50 and 100 percent of food intolerance sufferers have increased intestinal permeability. Increased intestinal permeability can be caused by food allergies and sensitivities, stress, infections, and low stomach acid, among other causes. Elevated levels of Zonulin are associated with Celiac Disease, Autoimmune disease, and Multiple Sclerosis, in addition to other chronic illnesses. In a healthy gut, there are healthy cell junctions and good nutrient absorption. In a leaky gut, however, the Villi are damaged, there is poor absorption and the cell junctions are loose. This means that bacteria and unwanted items can pass through the gut, as seen in the picture to the right. Zonulin Testing is best performed with the patient’s first FIT Test to provide a baseline for the Zonulin levels. This gives patients the opportunity to track their progress after implementing an elimination diet based on the FIT Test results. We recommend retesting when you retest your FIT.

More Resources on Zonulin


KBMO offers a mobile app to patients, available on iOS and Android devices. The mobile app allows patients to take their results on the go. Patient can also view their meal plans and cross reactivity on the app.